Regenerative Medicine: the future of aesthetic treatments
Growth factors, peptides and PRP (platelet rich plasma) have been around awhile in the cosmetic industry. Polynucleotides and exosomes are newer terms trending on social media and the focus of study within the scientific community honed on the future of aesthetics. These new kids on the block are different from their predecessors because they do something fundamentally different: they can reverse cell aging in key cells that are part of our skin – a concept termed bioregenerative aesthetics.
Skin aging is a natural process that is influenced by both intrinsic and extrinsic variables, such as genetic predisposition, hormone changes, UV radiation exposure, environmental toxins (pollution, smoking) and lifestyle (certain diets, poor sleep, high stress). These elements contribute to the development of wrinkles, fine lines, an uneven tone in our skin, and generalized symptoms of aging as well.
The fibroblast is the cell type in our skin that is responsible for the production of collagen, elastin and the extracellular matrix (ECM), which is the milieu surrounding these cells and makes up a large component of our skin. With aging, the amount and quality of collagen and elastin produced by fibroblasts decreases, as does the content of hyaluronic acid and other components in the ECM.
Stem cells are used to promote healing and reverse aging: they have been used for the past decade in dentistry, orthopedics and complex skin wounds. Harvesting the messengers within stem cells is a relatively new bioengineered technology in the field of regenerative science. Likewise, an important population of cells in our blood called platelets, which are in charge of repairing wounds, are also replete with intracellular messengers that promote healing and tissue regeneration and can also be reaped. These messengers are packaged in tiny “envelopes” and are known as exosomes.
Stem cells have the ability to become many different kinds of tissue and exhibit amazing plasticity and regenerative capabilities and have not yet accrued DNA damage as other cells do over the course of years. Platelets, while they have very specific functionality and do not have the ability to become other cells, are constantly being made by our bone marrow and are “young” cells. They have a life-span of 7-10 days. They are the most important cells in our bodies in charge repairing tissue when it is wounded – they also exert many other functions that are vital to our survival.
More formally, exosomes are small cell membrane- bound “packages” filled with biological information such as microRNAs, messenger RNA, lipids, proteins, peptides, vitamins and other vital building blocks, that originate in the cytoplasm (inside the walls of a cell) and are exported out of the cell of origin. They are the means by which cells communicate with their surroundings.
When the information within these exosomes reaches their target cell, they influence gene expression, allowing these older cells to behave like younger, non-damaged cells. This results in the production of proteins and other products such as the ones made by younger cells. It is analogous to “updating the software” in a computer.
These molecules can reverse the aging in their target tissue, allowing for the production of healthier collagen and elastin, decreased inflammation which is a hallmark of aging, increase their metabolic activity and promote better utilization of essential components such as amino acids and vitamins. In the skin this translates into less wrinkles, increases elasticity and firmness, decreases pigmentation in the skin, and helps reverse damage from environmental and external stressors. These are also utilized for hair growth and greatly enhance the health of hair.
At DTC Dermatology we carry a state-of-the-art product called Plated, which was developed by a team of physician scientists at the Mayo Clinic. It is a shelf stable formulation of platelet derived exosomes for daily, topical application. You can learn more about Plated products by visiting:
Polynucleotides are biocompatible fragments of DNA derived from purified DNA, often sourced from the gonads of fish, such as salmon or trout, known as sodium DNA (or “salmon sperm” on social media). They are used as regenerative agents. These fragments need to reach the dermal layer of our skin via tiny needles or be applied on the skin after laser procedures, RF microneedling or chemical peels. Once they are in the dermis, they signal and stimulate fibroblasts, which promotes better-quality collagen and elastin synthesis, reduces the damaging effects of radical oxygen species and helps repair damaged skin. They are employed to augment the results of many different skin treatments resulting in:
- Fine lines and wrinkle improvement
- Skin texture and tone improvement
- Acne scar reduction
- Reduction in the size of enlarged pores
- Decreased redness and inflammation
- Reduced hyperpigmentation
- Accelerated post-procedure recovery
- Aids in hair regrowth, improved scalp health, and luminous and stronger hair
At DTC Dermatology we are using Lumicen, which contains 3% Sodium DNA ( referred to as salmon sperm in social media). It is a potent biostimulator with anti-inflammatory and anti-oxidant properties, as well as bio-restructuring capabilities which provides enhanced collagen and elastin synthesis, resulting in skin tightening, lessening redness, improving hyperpigmentation and providing skin “glow”.
Peptides are short chains of amino acids (usually <50), essentially mini-proteins. They can act as signaling molecules, hormones, or enzyme inhibitors. They are administered via injection, topically or orally, depending on the peptide. They typically bind to specific receptors on the surface of cells to trigger a biological response, like boosting collagen production, muscle growth, or fat metabolism. They act in a more targeted and specific fashion, usually affecting one pathway or receptor type. These molecules are synthesized in labs or derived from natural proteins.
Peptides work by:
- Stimulating fibroblast activity to boost collagen and elastin production
- Improving skin hydration and texture
- Acting as a scavenger of free radicals and reducing inflammation
- Promoting tissue repair by supporting cell proliferation
They are used as anti-aging products, to promote muscle growth, to break down fat in the skin, for skin tightening, pigmentation correction, stimulation of hair growth, among others. They do not have regenerative properties, but they greatly enhance the function of existing cells.
PDGF, or Platelet-Derived Growth Factor, is a naturally occurring protein in the body produced by platelets, which plays a critical role in regulating cell growth and division, especially in connective tissue cells (such as skin) and is involved in wound healing and tissue repair. It’s one of the key growth factors released by platelets when the body responds to injury—sending signals to nearby cells to activate regeneration. PDGF acts as a “first responder” after an injury.
PDGF acts like a biological messenger. When applied to the skin or scalp, it:
- Stimulates fibroblasts to produce collagen and elastin (for firmer, smoother skin)
- Encourages angiogenesis (the formation of new blood vessels to improve nutrient flow)
- Boosts keratinocyte proliferation (speeding up skin renewal)
- Activates hair follicle stem cells (supporting new growth in thinning areas)
- Helps remodel damaged or aging tissue
PDGF is an ideal substance for:
- Skin rejuvenation
- Hair restoration
- Post-laser or microneedling recovery
- Collagen stimulation
- Supporting wound healing and scar remodeling
PDGF is found in your own blood and to date has been traditionally obtained by drawing blood, spinning it down and concentrating it and known as PRP (Platelet-Rich Plasma). But advances in regenerative medicine have allowed us to deliver pure, lab-derived PDGF—such as Ariessence™ Pure PDGF—without needles, blood draws, or variability in quality. You can read more about Ariessence below.
DTC Dermatology Bio-Regenerative Aesthetic Procedures
The following treatments are highly customized cocktails consisting of various peptides, polynucleotides, hyaluronic acid and growth factors made by ProItalia and Toskani, both well know Italian companies who have been in the industry for over 50 years and used for decades in Europe and other parts of the world. These products are delivered via tiny microchannels created in the skin with hollow needles, which allow the active ingredients to penetrate more deeply and stimulate your skin’s natural repair mechanisms. The treatments are customizable, zone specific and can be tailored to suit your needs. Treatments are suitable for both men and women.
Light Eyes Contouring
Offers immediate results with ongoing improvement for up to 6 months reducing the appearance of dark circles, puffiness, periocular edema, fine lines & offers subtle volume.
- Hyaluronic acid and L-Ascorbic Acid for hydration and anti-oxidant properties
- Chamomile + Blackberry Extracts for anti-inflammatory properties
- Ruscosides – Isoflavinoids for capillary permeability and improvement in dark circles
- Argireline – Peptide to relax myofilaments connecting epidermis to smooth muscle which alleviate fine lines
- Ubiquinone – Antioxidant which inhibits tyrosinase activity
Bacio Lip Stimulator
Offers immediate and lasting results for up to 6 months, giving lips definition, ruby pigmentation, hydration and subtle volume. It is the first biostimulator for lips and the perioral area on the market.
- Hyaluronic acid and Vitamin B12 are used for hydration and antioxidant properties
Full Face Bioactive Complex Treatment
Lumicen: contains 3% polynucleotides (Sodium DNA – also known as salmon sperm)
- Biostimulator with anti-inflammatory and anti-oxidant properties, as well as bio-restructuring capabilities which provides enhanced collagen and elastin synthesis resulting in skin tightening, lessening redness, improving hyperpigmentation and providing skin “glow”.
Myotec:
- Immediate and long-lasting improvement of static lines and pore size without immobilizing deep muscles
Rich-PL: contains PLLA (same ingredient as Sculptra), hyaluronic acid, peptides and growth factors
- Biostimulator with for increased collagen and elastin with improved texture, hydration, pigmentation and tone
Full Face Treatment Series (a.k.a. Mermaid Facial) “Mermaid Facial” was branded by ProItalia
Each zone of the face receives a custom regenerative treatment – it combines all three of the procedures described above and involves 5 treatments over approximately 2 months:
- Initial treatment: Full face treatment which includes Light Eyes, Bacio Lip Stimulator and Bioactive Complex, followed by application of a Hydrinity HA mask to lock in treatment, increase product penetration and reduce inflammation
- Second treatment: Bacio Lip Stimulator and Light eyes
- Third treatment: Bacio Lip Stimulator and Light eyes
- Fourth treatment: Full face treatment
- Fifth treatment: Full face treatment
Results typically last 6-12 months (there is no PLLA in products used around the eyes and lips) and maintenance treatment may need to be performed every 6 months for eyes and lips and every 12 months for the full-face Bioactive Complex treatment.
Of note: Bioactive Complex can be used on neck and chest as well.
Ariessence™ - Pure PDGF
We are excited to introduce Ariessence™ Pure PDGF, a cutting-edge regenerative treatment harnessing the power of Platelet-Derived Growth Factor (PDGF)—without the need for blood draws or needles.
Whether you’re looking to restore thinning hair, revitalize aging skin, or enhance recovery from aesthetic procedures, Ariessence™ delivers growth-factor-driven regeneration in its purest form.
What Is Ariessence™ Pure PDGF?
Ariessence™ is a topical, bioidentical, bioengineered, sterile, highly purified, concentrated PDGF formula that delivers potent growth signals directly to skin cells and hair follicles. Unlike traditional PRP (Platelet-Rich Plasma), which requires drawing and processing your own blood, Ariessence™ provides pharmaceutical-grade recombinant PDGF— in a sterile, consistent, and needle-free fashion.
PDGF plays a key role in wound healing and tissue regeneration by stimulating:
- Fibroblast activation (collagen and elastin production)
- Angiogenesis (formation of new blood vessels)
- Keratinocyte proliferation (epidermal renewal)
- Hair follicle stem cell stimulation (hair regrowth and strengthening)
Who Is It For?
Ariessence™ is ideal for patients seeking non-invasive regenerative benefits for the treatment of:
- Hair thinning / shedding
- Fine lines and skin laxity
- Texture irregularities and dullness
- Post-procedure healing support (microneedling, laser, RF, and chemical peels)
- Patients who are not candidates for PRP or prefer blood-free options
Treatment Experience
No needles. No downtime.
Your provider will apply Ariessence™ to pretreated skin or scalp, after procedures that enhance absorption such as traditional microneedling, RF microneedling, chemical peels or laser treatments. Application of Ariessence will accelerate wound healing and greatly improve the outcomes of your procedures.
Why Choose Ariessence™ Over PRP?
Features
- Blood draw
- Consistency
- Needle-free
- Growth factor purity
- Use after microneedling/laser
- Comfort
- Cost efficiency
Ariessence™ Pure PDGF
- None required
- Pharmaceutical-grade
- Yes
- Isolated PDGF
- Excellent
- Painless
- Often lower per session
Traditional PRP
- Yes
- No
- No
- Mixed platelet content
- Excellent
- Injections required
- Higher cost with blood processing
Is Ariessence™ Right for Me?
If you’re interested in a safe, elegant, and science-backed regenerative therapy—with no needles or downtime—Ariessence™ may be the perfect choice. Our providers will assess your goals and customize a protocol just for you.
To learn more, visit
Ariessence Pure PDGF+ Details – LRM Aesthetics, Inc.
Schedule a one-on-one consultation to discover how Ariessence™ can elevate your aesthetic or hair restoration journey.
To schedule a consultation call: